Revolution Medicines Begins Treating Patients in Phase 3 RASolute 309 Trial Evaluating RASONQUE™ (daraxonrasib) Plus Zoldonrasib as First-Line Treatment for Metastatic RAS G12D Pancreatic Cancer
Revolution Medicines announced it has begun treating patients in RASolute 309, a global, randomized Phase 3 trial evaluating the combination of RASONQUE (daraxonrasib) and zoldonrasib as a first-line treatment for adults with metastatic RAS G12D pancreatic adenocarcinoma. The trial is designed to assess the two investigational RAS(ON) inhibitors in this patient population.
Why it matters — This marks the initiation of a pivotal Phase 3 trial for a key combination therapy in a difficult-to-treat pancreatic cancer setting, representing a significant clinical development milestone for Revolution Medicines' pipeline.