Roswell Park, Generate Biomedicines Launch Exclusive Clinical Trial of ‘Armored' CAR T Therapy for Ovarian Cancer
Roswell Park Comprehensive Cancer Center and Generate Biomedicines launched an exclusive clinical trial of GB-5267, an AI-engineered "armored" CAR T cell therapy for ovarian cancer, with the first patient treated. The therapy targets MUC16, a biomarker over-expressed in over 80% of ovarian tumors, and is designed to avoid pre-infusion chemotherapy and its side effects.
Why it matters — This marks the first next-generation cell therapy for ovarian cancer to enter clinical trials, representing a key clinical milestone for Generate Biomedicines' AI-driven cell therapy pipeline.