Korro Reports Best-in-Class Preclinical Data for KRRO-111 Demonstrating Potential to Benefit Lung and Liver Manifestations of Alpha-1 Antitrypsin Deficiency
Korro reported preclinical KRRO-111 results in repeat-dose mouse studies, including more than 95% SERPINA1 mRNA editing, increased circulating functional M-AAT and total AAT, and up to 95% reduction in pathogenic hepatic Z-AAT. The company said the program may address both lung and liver manifestations of AATD and expects a regulatory submission in the first half of 2027.
Why it matters — The findings outline KRRO-111’s preclinical profile and development timeline for investors tracking Korro’s AATD program.