TransCode Reports Continued Disease Stabilization and Extended Treatment Duration with TTX-MC138 in Ongoing Phase 1a Clinical Trial Follow-Up
TransCode Therapeutics reported updated follow-up data from its ongoing Phase 1a clinical trial of TTX-MC138 in heavily pretreated patients with advanced solid tumors. In the 14 efficacy-evaluable patients, 71.4% achieved stable disease, 57.1% had disease control through three months, 36.7% through six months, and three patients remained progression-free at one year, with the primary endpoint met and no dose-limiting toxicities reported. Exploratory blood RNA-sequencing indicated treatment-associated antitumor immune activation and biological features linked to stable disease.
Why it matters — This update strengthens evidence of TTX-MC138's antitumor activity and extended disease stabilization in a difficult-to-treat patient population, which is relevant to RNAZ watchers assessing the drug's clinical progress.