RYTMRYTMHealthcare · Biotechnology

RYTM Stock Forecast: Rhythm Pharmaceuticals, Inc. Price Predictions for 2026-2027

Last close, 23 Oct 2026
$89
−1.88% on the day

The 19 Wall Street analysts covering Rhythm Pharmaceuticals, Inc. hold a median 12-month price target of $143 — +60.3% from the last close. Ticker Nerd's systematic factor model, run across ~4,600 US stocks, ranks it 87 of 100 as at 24 Oct 2026 — inside the top quartile. Here, the model and the Street point the same way.

Market cap
$6.1B
Ticker Nerd rank
87/ 100
Median analyst target
$143
Analysts covering
19
Revenue$71.3M+46.9% y/y
Operating income−$48.6M
Net income−$49.3M
Free cash flow−$9.2M
Quarterly, 8 quarters to 30 June 2026 · latest quarter's figure shown
Total return, dividends reinvested
1W
+3.5%
1M
−9.2%
YTD
−16.7%
1Y
−18.3%
From 52W high
−24.2%
From 52W low
+17.6%
$76
$118
52-week range, adjusted closes · the dot is the last close
Ticker Nerd rank

RYTM stock analysis: one number for the whole business

Consensus tells you what everyone already believes. The model scores Rhythm Pharmaceuticals, Inc. on its factor families — the same systematic rank behind the Ticker Nerd portfolio.

Where the model ranks itAs at 24 Oct 2026
87/ 100

Percentile across ~4,600 US stocks on Ticker Nerd’s systematic factor model. Higher is better. How the model is built and tested

Revisions
89
Value
87
Quality
81
Issuance
79
Volatility
65
Momentum
64
Accruals
56
Growth
47
Size
20

Revisions (89): Analysts have, on balance, been raising their forecasts.

Growth (47): Sales and profits are flat, shrinking, or growing more slowly than they were.

Size (20): Larger than most of the companies we track — more scrutinised, less often mispriced.

Built and run by Aslam Ghouse, an ex-Goldman Sachs quant trader with fourteen years in markets.

Wall Street

RYTM stock forecast 2026-2027: analyst price targets & predictions

The bullish and bearish analyst opinions on RYTM, reported as data — targets and ratings, the market's view beside the model's.

Share price and the analyst range, 12 monthsAdjusted close, US dollars
$80$100$120$140$160Jan 26Apr 26Jul 26Oct 26RYTMHigh $160Median $143Low $120

Price targets and ratings are third-party analyst estimates, reported here as data. They are not Ticker Nerd forecasts, and they are frequently wrong.

Data provided by Twelve Data

What Wall Street says19 analysts
17 Buy2 Hold0 Sell
Low $120Median $143High $160

The green dot is the last close — the median target sits +60.3% from it.

Recent analyst actionsNewest first

Of the 20 most recent actions, 7 moved their price target up and 1 moved it down.

DateFirmActionRatingTarget
16 Oct 2026William BlairInitiatesOutperform—
15 Oct 2026JP MorganMaintainsOverweight$146 → $145
12 Oct 2026HC Wainwright & Co.MaintainsBuy$105 → $130
8 Oct 2026RBC CapitalMaintainsOutperform$155 → $159
8 Oct 2026RBC CapitalMaintainsOutperform—
14 Sept 2026Leerink PartnersAssumesOutperform$133
28 Aug 2026Deutsche BankInitiatesHold—
28 Aug 2026Deutsche BankInitiatesHold$120
7 Aug 2026JP MorganMaintainsOverweight$145 → $146
7 Aug 2026JP MorganMaintainsOverweight—
5 Aug 2026CitigroupMaintainsBuy$142 → $143
5 Aug 2026CitigroupMaintainsBuy—
5 Aug 2026CitizensMaintainsMarket Outperform$155 → $160
5 Aug 2026CitizensMaintainsMarket Outperform—
5 Aug 2026RBC CapitalMaintainsOutperform$141 → $155
5 Aug 2026RBC CapitalMaintainsOutperform—
27 July 2026JP MorganInitiatesOverweight$145
27 July 2026JP MorganInitiatesOverweight—
7 July 2026RBC CapitalMaintainsOutperform—
7 July 2026RBC CapitalMaintainsOutperform$137 → $141

Price targets and ratings are third-party analyst estimates, reported here as data. They are not Ticker Nerd forecasts, and they are frequently wrong.

Market Radar

This page is one stock. Monday covers all of them.

RYTM appears in the Radar on the weeks it earns a place.

  • Market Radar, every Monday: the week's biggest rank moves across ~4,600 US stocks, and the reason for each.
  • The AI build-out map, free: every AI company we track, part by part, and one part in full with each verdict.

Free. Unsubscribe any time.

Performance

RYTM vs the S&P 500

Both lines are total return — dividends reinvested — so the comparison is honest on both sides.

Over the twelve months to 23 Oct 2026, Rhythm Pharmaceuticals, Inc. returned −18.3% against +14.3% for the S&P 500, dividends included.

RYTM vs S&P 500, last 12 monthsTotal return, rebased to 100
708090100110120Jan 26Apr 26Jul 26Oct 26RYTMS&P 500

Download this chart as an image — free to reuse; link this page as the source.

Data provided by Twelve Data

Estimates

RYTM analyst estimate revisions

Not the forecast itself — the direction analysts are revising it. Revision direction is one of the model's factor families.

Which way the estimates are movingNext fiscal year
Analysts raising
2
Analysts cutting
1
Fundamentals

Rhythm Pharmaceuticals, Inc. (RYTM) financial data

A margin means little on its own. Each bar marks where the figure sits across the whole US universe we score.

Valuation
Trailing P/E
−28.7×

Cheaper than 97% of US stocks

Price / sales
25.6×

Cheaper than 7% of US stocks

Price / book
59.7×

Cheaper than 2% of US stocks

EV / EBITDA
−30.3×

Cheaper than 92% of US stocks

Growth & margins
Revenue growth (YoY)
46.9%

Higher than 85% of US stocks

Earnings growth (YoY)
46.9%

Higher than 73% of US stocks

Gross margin
87.5%

Higher than 95% of US stocks

Operating margin
−68.1%

Higher than 15% of US stocks

Net margin
−85.6%

Higher than 7% of US stocks

Returns & dividend
Return on equity
−117.0%

Higher than 12% of US stocks

Return on assets
−31.0%

Higher than 13% of US stocks

Dividend yield
0.0%

Higher than 1% of US dividend payers

Bars mark the percentile across the ~4,600 US stocks Ticker Nerd covers, among those reporting the figure.

Key statistics

Rhythm Pharmaceuticals, Inc. (RYTM) statistics: revenue, profit & scale

The headline figures, each with its date. Every row carries its own link — cite it straight from here.

  • Rhythm Pharmaceuticals, Inc. has a market value of $6.1B and an enterprise value of $6.0B.

  • Revenue in the twelve months to 30 June 2026: $239.9M. The latest quarter grew 46.9% year on year.

  • Net income over the same four quarters: −$205.3M, a −85.6% net margin.

  • Diluted earnings per share, trailing twelve months: $−3.11.

  • Free cash flow in the twelve months to 30 June 2026: −$106.3M.

  • Shares outstanding: 68.8M.

  • Trailing P/E: −28.7×; forward P/E: −142.0× — the forward figure prices analyst consensus estimates, not reported earnings.

  • Forward dividend yield: 0.00%, paying out 0% of earnings.

  • Rhythm Pharmaceuticals, Inc. employs 414 people — $580K of revenue per employee.

Statement figures: company filings via Twelve Data, four quarters to 30 June 2026 · market figures as at 26 Oct 2026

Data provided by Twelve Data

Peers

RYTM vs competitors

The nearest names by industry and size, scored by the same model — like for like.

Its peer group, ranked by the same modelBiotechnology
CompanyMarket capTKN rank
RYTMRhythm Pharmaceuticals, Inc.$6.1B87
IOVAIovance Biotherapeutics, Inc.$6.3B93
LGNDLigand Pharmaceuticals, Inc.$6.0B71
IMVTImmunovant, Inc.$5.7B39
MANEVeradermics, Inc.$5.7B3
PRAXPraxis Precision Medicines, Inc.$6.9B42
CGONCG Oncology, Inc.$5.4B17

Look up any of the roughly 4,600 stocks we score.

The rank is the raw material. Whether the rules would actually own Rhythm Pharmaceuticals, Inc. — and when they’d sell — is the membership. See the Ticker Nerd 20 →

News

Latest RYTM news & analysis

Rhythm Pharmaceuticals Announces Commercial Launch of IMCIVREE® (setmelanotide) in Japan for Patients with Acquired Hypothalamic Obesity

GlobeNewsWire · 13 Oct 2026positive

Rhythm Pharmaceuticals announced the commercial launch of IMCIVREE (setmelanotide) in Japan for patients with acquired hypothalamic obesity. The launch follows MHLW approval and the drug’s inclusion on Japan’s National Health Insurance drug price list.

Why it matters — The launch makes IMCIVREE the first approved therapy in Japan for acquired hypothalamic obesity, a development relevant to RYTM’s commercial activity.

Rhythm Pharmaceuticals (RYTM) Upgraded to Buy: Here's What You Should Know

Zacks Investment Research · 13 Oct 2026positive

Rhythm Pharmaceuticals (RYTM) was upgraded to Zacks Rank #2 (Buy), reflecting growing optimism about its earnings prospects. The excerpt says this optimism might drive the stock higher in the near term.

Why it matters — RYTM watchers may note the upgrade as a sign of increased optimism about the company's earnings prospects.

Rhythm Pharmaceuticals Announces Health Canada Approval of IMCIVREE® (setmelanotide) for Weight Management in Adult and Pediatric Patients 4 years of Age and Older with Acquired Hypothalamic Obesity

GlobeNewsWire · 22 Sept 2026positive

Rhythm Pharmaceuticals announced that Health Canada has approved IMCIVREE (setmelanotide) for the additional indication of weight management in adult and pediatric patients aged 4 years and older with acquired hypothalamic obesity (HO).

Why it matters — This regulatory approval expands the potential market for Rhythm Pharmaceuticals' IMCIVREE into a new indication and geography, broadening its commercial opportunity for RYTM watchers.

Rhythm Pharmaceuticals, Inc. (RYTM) Presents at Morgan Stanley 24th Annual Global Healthcare Conference Transcript

Seeking Alpha · 15 Sept 2026neutral

Rhythm Pharmaceuticals presented at the Morgan Stanley 24th Annual Global Healthcare Conference, and a transcript of the presentation was published by Seeking Alpha. The company participated in the conference as part of its investor outreach.

Why it matters — The presentation gives RYTM watchers direct insight into the company's current business update and management commentary delivered at a major healthcare investment conference.

FAQ

Frequently asked questions about RYTM stock

What is the RYTM stock price forecast for 2026-2027?

The 19 Wall Street analysts covering Rhythm Pharmaceuticals, Inc. have a median 12-month price target of $143, with estimates ranging from $120 to $160. These are third-party analyst estimates, not Ticker Nerd forecasts, and they are frequently wrong.

Is RYTM stock a buy right now?

Of the 19 analysts covering Rhythm Pharmaceuticals, Inc., 17 rate it a Buy, 2 a Hold and 0 a Sell. Ticker Nerd's systematic factor model ranks Rhythm Pharmaceuticals, Inc. 87 out of 100 across roughly 4,600 US stocks as at 24 Oct 2026. None of this is personal advice — it does not consider your circumstances.

How does Ticker Nerd's model rank RYTM?

As at 24 Oct 2026, Rhythm Pharmaceuticals, Inc. ranks 87 out of 100 on Ticker Nerd's systematic factor model — a percentile across roughly 4,600 US stocks, built from its factor families. Its strongest factor family is Revisions (89 of 100).

Will RYTM stock go up?

No one can know that. What the data says: the median 12-month target from 19 analysts implies +60.3% from the last close, and Ticker Nerd's factor model ranks Rhythm Pharmaceuticals, Inc. 87 out of 100 as at 24 Oct 2026. Analyst targets are third-party estimates and frequently wrong; none of this is personal advice.

What is the RYTM stock forecast for 2030?

No analyst covering Rhythm Pharmaceuticals, Inc. publishes a 2030 price target — Wall Street targets run 12 to 18 months out. Sites quoting a 2030 price for RYTM are extrapolating price history, which says nothing about the business. The furthest attributed numbers are the current analyst targets: $120 to $160 over the next 12 months.

How has RYTM stock performed over the past year?

Rhythm Pharmaceuticals, Inc. returned -18.3% over the 12 months to 23 Oct 2026, with dividends reinvested. Past performance does not indicate future returns.

What does Rhythm Pharmaceuticals, Inc. do?

Rhythm Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company focused on developing and commercializing therapies for rare neuroendocrine diseases.

What is the latest news on RYTM?

The most recent item we track (GlobeNewsWire, 21 Oct 2026): "Rhythm Pharmaceuticals to Report Third Quarter 2026 Financial Results on Tuesday, November 3, 2026". Rhythm Pharmaceuticals announced it will report its third-quarter 2026 financial results and provide a corporate update during a live conference call and webcast at 8:00 a.m. ET on Tuesday, November 3, 2026.

Company

About Rhythm Pharmaceuticals, Inc.

Rhythm Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company focused on developing and commercializing therapies for rare neuroendocrine diseases. The company’s lead product, IMCIVREE (setmelanotide), is a precision medicine used to treat severe obesity and hyperphagia associated with specific melanocortin-4 receptor pathway disorders and acquired hypothalamic obesity. Rhythm Pharmaceuticals serves patients with serious rare conditions that are often underserved by conventional obesity treatments, and its work centers on targeted treatments designed for defined genetic and clinical populations. Based in Boston, Massachusetts, and founded in 2008, the company operates within specialty medicine, where it addresses unmet needs in rare metabolic and endocrine diseases through approved therapies and ongoing clinical development.

CEO Dr. David P. Meeker M.D. · 414 employees · United States · https://rhythmtx.com