Veru Advances Oral Sabizabulin Following Positive Preclinical Data Showing Potent Anticancer Activity in Human Daraxonrasib (Revolution Medicines' RASONQUE™) Resistant Pancreatic Cancer into a Planned Phase 2 Clinical Trial
Veru announced it is advancing oral sabizabulin into a planned Phase 2 clinical trial following positive preclinical data showing potent anticancer activity (IC50=18.2nM) in daraxonrasib-resistant human pancreatic cancer cells. The company noted sabizabulin had a good safety profile and promising efficacy in a previous Phase 1b/2 study of 80 subjects with castration-resistant and taxane-resistant metastatic prostate cancer.
Why it matters — This marks clinical progress for sabizabulin into a new indication, pancreatic cancer, building on encouraging preclinical efficacy against daraxonrasib resistance and prior safety data in prostate cancer.