SYRESYREHealthcare · Biotechnology

SYRE Stock Forecast: Spyre Therapeutics, Inc. Price Predictions for 2026-2027

Last close, 6 Oct 2026
$80
−13.60% on the day

The 17 Wall Street analysts covering Spyre Therapeutics, Inc. hold a median 12-month price target of $122 — +52.3% from the last close. Ticker Nerd's systematic factor model, run across ~4,600 US stocks, ranks it 46 of 100 as at 6 Oct 2026 — in the lower half.

Market cap
$8.2B
Ticker Nerd rank
46 / 100
Median analyst target
$122
Analysts covering
17
Revenue$0.0
Operating income−$81.6M
Net income−$36.2M
Free cash flow−$69.9M
Quarterly, 8 quarters to 30 June 2026 · latest quarter's figure shown
Total return, dividends reinvested
1W
−5.4%
1M
−10.0%
YTD
+144.5%
1Y
+380.6%
From 52W high
−26.5%
From 52W low
+400.1%
$16
$109
52-week range, adjusted closes · the dot is the last close
Ticker Nerd rank

SYRE stock analysis: one number for the whole business

Consensus tells you what everyone already believes. The model scores Spyre Therapeutics, Inc. on its factor families — the same systematic rank behind the Ticker Nerd portfolio.

Where the model ranks itAs at 6 Oct 2026
46 / 100

Percentile across ~4,600 US stocks on Ticker Nerd’s systematic factor model. Higher is better. How the model is built and tested

Momentum
92
Value
79
Quality
72
Volatility
52
Revisions
49
Growth
49
Issuance
28
Size
19
Accruals
16

Momentum (92): The shares have been drifting up relative to others.

Accruals (16): A large share of reported profit has not shown up as cash, or the balance sheet is expanding quickly — both tend to unwind.

Built and run by Aslam Ghouse, an ex-Goldman Sachs quant trader with fourteen years in markets.

Wall Street

SYRE stock forecast 2026-2027: analyst price targets & predictions

The bullish and bearish analyst opinions on SYRE, reported as data — targets and ratings, the market's view beside the model's.

Share price and the analyst range, 12 monthsAdjusted close, US dollars
$0$20$40$60$80$100$120$140Jan 26Apr 26Jul 26Oct 26SYREHigh $130Median $122Low $97

Price targets and ratings are third-party analyst estimates, reported here as data. They are not Ticker Nerd forecasts, and they are frequently wrong.

Data provided by Twelve Data

What Wall Street says17 analysts
16 Buy1 Hold0 Sell
Low $97Median $122High $130

The green dot is the last close — the median target sits +52.3% from it.

Recent analyst actionsNewest first

Of the 20 most recent actions, 4 moved their price target up and 3 moved it down.

DateFirmActionRatingTarget
1 Oct 2026BTIGReiteratesBuy$121
1 Oct 2026JP MorganInitiatesOverweight$110
9 Sept 2026WedbushReiteratesOutperform—
9 Sept 2026WedbushReiteratesOutperform$123
8 Sept 2026BTIGReiteratesBuy$121
8 Sept 2026BTIGReiteratesBuy—
26 Aug 2026BTIGMaintainsBuy—
26 Aug 2026BTIGMaintainsBuy$132 → $121
26 Aug 2026Deutsche BankMaintainsBuy$135 → $127
26 Aug 2026Deutsche BankMaintainsBuy—
26 Aug 2026WedbushMaintainsOutperform—
26 Aug 2026WedbushMaintainsOutperform$130 → $123
11 Aug 2026BTIGMaintainsBuy$112 → $132
11 Aug 2026BTIGMaintainsBuy—
5 Aug 2026GuggenheimMaintainsBuy$115 → $130
5 Aug 2026GuggenheimMaintainsBuy—
5 Aug 2026WedbushMaintainsOutperform$100 → $130
5 Aug 2026WedbushMaintainsOutperform—
5 Aug 2026Wells FargoMaintainsOverweight$90 → $115
5 Aug 2026Wells FargoMaintainsOverweight—

Price targets and ratings are third-party analyst estimates, reported here as data. They are not Ticker Nerd forecasts, and they are frequently wrong.

Market Radar

This page is one stock. Monday covers all of them.

Computed off the Friday close and sent before the US open.

Market Radar reports the week’s largest rank changes across roughly 4,600 US stocks, the factor behind each one, and where the market went. SYRE appears on the weeks it earns a place.

Free, every Monday. Unsubscribe any time.

Performance

SYRE vs the S&P 500

Both lines are total return — dividends reinvested — so the comparison is honest on both sides.

Over the twelve months to 6 Oct 2026, Spyre Therapeutics, Inc. returned +380.6% against +17.3% for the S&P 500, dividends included.

SYRE vs S&P 500, last 12 monthsTotal return, rebased to 100
100200300400500600700Jan 26Apr 26Jul 26Oct 26SYRES&P 500

Download this chart as an image — free to reuse; link this page as the source.

Data provided by Twelve Data

Estimates

SYRE analyst estimate revisions

Not the forecast itself — the direction analysts are revising it. Revision direction is one of the model's factor families.

Which way the estimates are movingNext fiscal year
Analysts raising
9
Analysts cutting
3
Fundamentals

Spyre Therapeutics, Inc. (SYRE) financial data

A margin means little on its own. Each bar marks where the figure sits across the whole US universe we score.

Valuation
Trailing P/E
1.7×

Cheaper than 70% of US stocks

Price / sales
—
Price / book
8.6×

Cheaper than 11% of US stocks

EV / EBITDA
−31.3×

Cheaper than 92% of US stocks

Growth & margins
Revenue growth (YoY)
—
Earnings growth (YoY)
—
Gross margin
—
Operating margin
0.0%

Higher than 32% of US stocks

Net margin
0.0%

Higher than 30% of US stocks

Returns & dividend
Return on equity
−23.0%

Higher than 30% of US stocks

Return on assets
−19.8%

Higher than 19% of US stocks

Dividend yield
0.0%

Higher than 1% of US dividend payers

Bars mark the percentile across the ~4,600 US stocks Ticker Nerd covers, among those reporting the figure.

Key statistics

Spyre Therapeutics, Inc. (SYRE) statistics: revenue, profit & scale

The headline figures, each with its date. Every row carries its own link — cite it straight from here.

  • Spyre Therapeutics, Inc. has a market value of $8.2B and an enterprise value of $7.2B.

  • Revenue in the twelve months to 30 June 2026: $0.0.

  • Net income over the same four quarters: −$178.9M.

  • Diluted earnings per share, trailing twelve months: $−2.05.

  • Free cash flow in the twelve months to 30 June 2026: −$208.9M.

  • Shares outstanding: 88.1M.

  • Trailing P/E: 1.7×; forward P/E: −26.3× — the forward figure prices analyst consensus estimates, not reported earnings.

  • Forward dividend yield: 0.00%, paying out 0% of earnings.

  • Spyre Therapeutics, Inc. employs 125 people.

Statement figures: company filings via Twelve Data, four quarters to 30 June 2026 · market figures as at 6 Oct 2026

Data provided by Twelve Data

Peers

SYRE vs competitors

The nearest names by industry and size, scored by the same model — like for like.

Its peer group, ranked by the same modelBiotechnology
CompanyMarket capTKN rank
SYRESpyre Therapeutics, Inc.$8.2B
46
IONSIonis Pharmaceuticals, Inc.$7.3B
42
IMVTImmunovant, Inc.$6.5B
38
RYTMRhythm Pharmaceuticals, Inc.$6.2B
88
PRAXPraxis Precision Medicines, Inc.$7.7B
41
CAICaris Life Sciences, Inc.$7.8B
36
LGNDLigand Pharmaceuticals, Inc.$5.8B
68

Look up any of the roughly 4,600 stocks we score.

The rank is the raw material. Whether the rules would actually own Spyre Therapeutics, Inc. — and when they’d sell — is the membership. See the Ticker Nerd 20 →

News

Latest SYRE news & analysis

Spyre Therapeutics Announces Pricing of $350.0 Million Public Offering of Common Stock

GlobeNewsWire · 6 Oct 2026neutral

Spyre Therapeutics announced the pricing of its underwritten public offering of 4,117,648 shares of common stock at $85.00 per share, with expected gross proceeds of approximately $350.0 million. The underwriters were also granted a 30-day option to purchase up to an additional approximately $52.5 million of shares, with the offering expected to close on or about October 7, 2026.

Why it matters — SYRE watchers would care because the offering details the company's capital raise, including share pricing, gross proceeds, and underwriter option terms ahead of the anticipated closing.

Spyre Therapeutics Announces Proposed Public Offering of its Common Stock

GlobeNewsWire · 5 Oct 2026neutral

Spyre Therapeutics announced it has commenced an underwritten public offering of its common stock, and expects to grant underwriters a 30-day option to purchase an additional 15% of the shares offered under the same terms. The offering is subject to market and other conditions, with no assurance as to completion or final size or terms.

Why it matters — A public stock offering could affect Spyre's share count and capital position, which SYRE shareholders typically watch closely.

Spyre Therapeutics Announces Grants of Inducement Awards

GlobeNewsWire · 2 Oct 2026neutral

Spyre Therapeutics announced that its Compensation Committee approved equity inducement awards, consisting of stock options for 21,424 shares and 6,604 restricted stock units, granted to two non-executive employees on October 1, 2026 under the company's 2018 Equity Inducement Plan. The awards were material to each employee's acceptance of employment and were made in accordance with Nasdaq Listing Rule 5635(c)(4).

Why it matters — SYRE watchers would note this as a routine corporate-governance disclosure concerning employee equity incentives under the inducement plan, reflecting standard hiring practice.

Spyre Therapeutics, Inc. (SYRE) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcript

Seeking Alpha · 9 Sept 2026neutral

Spyre Therapeutics, Inc. (SYRE) presented at Citigroup's Biopharma Back to School Summit 2026, with a transcript of the presentation published by Seeking Alpha. The presentation appears to be part of the company's investor outreach and conference participation.

Why it matters — A SYRE watcher would be interested in the remarks made by company leadership at a major industry investment conference, which may offer insight into the company's strategic position and pipeline.

Spyre's Anti-IL-23 Antibody Meets Goal in Ulcerative Colitis Study

Zacks Investment Research · 9 Sept 2026positive

Spyre Therapeutics announced that its anti-IL-23 antibody SPY003 met its goal in a phase II study for ulcerative colitis, according to Zacks Investment Research. The positive data is said to strengthen Spyre's multi-mechanism inflammatory bowel disease strategy.

Why it matters — A SYRE watcher would care because positive phase II data for SPY003 bolsters the company's IBD pipeline and multi-mechanism approach, a key part of its development strategy.

FAQ

Frequently asked questions about SYRE stock

What is the SYRE stock price forecast for 2026-2027?

The 17 Wall Street analysts covering Spyre Therapeutics, Inc. have a median 12-month price target of $122, with estimates ranging from $97 to $130. These are third-party analyst estimates, not Ticker Nerd forecasts, and they are frequently wrong.

Is SYRE stock a buy right now?

Of the 17 analysts covering Spyre Therapeutics, Inc., 16 rate it a Buy, 1 a Hold and 0 a Sell. Ticker Nerd's systematic factor model ranks Spyre Therapeutics, Inc. 46 out of 100 across roughly 4,600 US stocks as at 6 Oct 2026. None of this is personal advice — it does not consider your circumstances.

How does Ticker Nerd's model rank SYRE?

As at 6 Oct 2026, Spyre Therapeutics, Inc. ranks 46 out of 100 on Ticker Nerd's systematic factor model — a percentile across roughly 4,600 US stocks, built from its factor families. Its strongest factor family is Momentum (92 of 100).

Will SYRE stock go up?

No one can know that. What the data says: the median 12-month target from 17 analysts implies +52.3% from the last close, and Ticker Nerd's factor model ranks Spyre Therapeutics, Inc. 46 out of 100 as at 6 Oct 2026. Analyst targets are third-party estimates and frequently wrong; none of this is personal advice.

What is the SYRE stock forecast for 2030?

No analyst covering Spyre Therapeutics, Inc. publishes a 2030 price target — Wall Street targets run 12 to 18 months out. Sites quoting a 2030 price for SYRE are extrapolating price history, which says nothing about the business. The furthest attributed numbers are the current analyst targets: $97 to $130 over the next 12 months.

How has SYRE stock performed over the past year?

Spyre Therapeutics, Inc. returned +380.6% over the 12 months to 6 Oct 2026, with dividends reinvested. Past performance does not indicate future returns.

What does Spyre Therapeutics, Inc. do?

Spyre Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing long-acting antibodies and antibody combinations for inflammatory bowel disease and other immune-mediated disorders.

What is the latest news on SYRE?

The most recent item we track (GlobeNewsWire, 6 Oct 2026): "Spyre Therapeutics Announces Pricing of $350.0 Million Public Offering of Common Stock". Spyre Therapeutics announced the pricing of its underwritten public offering of 4,117,648 shares of common stock at $85.00 per share, with expected gross proceeds of approximately $350.0 million. The underwriters were also granted a 30-day option to purchase up to an additional approximately $52.5 million of shares, with the offering expected to close on or about October 7, 2026.

Company

About Spyre Therapeutics, Inc.

Spyre Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing long-acting antibodies and antibody combinations for inflammatory bowel disease and other immune-mediated disorders. Spyre Therapeutics concentrates on advancing therapies designed to improve disease control, extend treatment durability, and simplify dosing for patients with ulcerative colitis, Crohn’s disease, and related rheumatic conditions. Its current pipeline centers on investigational antibody programs targeting key immune pathways, including α4β7, TL1A, and IL-23, with both standalone and combination approaches under development. The company is primarily engaged in biopharmaceutical research and clinical development, and its work is centered on creating next-generation immunology treatments for complex chronic diseases. Headquartered in Waltham, Massachusetts, Spyre Therapeutics serves as a specialized player in the biotech sector, where it contributes to the advancement of targeted therapies for gastrointestinal and immune-mediated diseases.

CEO Dr. Cameron Turtle DPHIL, Ph.D. · 125 employees · United States · https://www.spyre.com